Pipecuronium

Indications
 Intravenous
Muscle relaxant in general anaesthesia, Facilitate endotracheal intubation
Adult: Initial dose: 80-100 mcg/kg. Subsequent doses: 10-20 mcg/kg. Initial dose following suxamethonium admin or in patients at high risk: 50-60 mcg/kg. Initial dose for caesarean section: 35 mcg/kg.

Special Populations: Reduce dose to 50 mcg/kg body wt in patients with renal impairment and CrCl <40 mL/min.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Pulmonary disease, respiratory insufficiency, asthma, neuromuscular disease, dehydration, severely ill patients, hepatic or renal impairment. Doses in obese patients should be based on patient's ideal body weight. Pregnancy, lactation.
Adverse Reactions
 Transient hypotension, bradycardia, reduced cardiac output.
Potentially Fatal: Anaphylactic reactions and malignant hyperthermia.
Overdose Reactions
 Prolonged apnoea due to paralysis of the intercostal muscles and diaphragm, with CV collapse and effects of histamine release.
Drug Interactions
 Actions antagonised by cholinesterases and long term carbamazepine, phenytoin or corticosteroids usage. Enhanced block when used with drugs that have neuromuscular blocking activity such as lidocaine, quinidine, verapamil and aminoglycosides.
Potentially Fatal: Effects enhanced by volatile inhalational anaesthetics, ketamine (IV), antiarrhythmics, antibacterials, K depleting diuretics, parenteral Mg salts.
See Below for More pipecuronium Drug Interactions
Mechanism of Actions
 Pipecuronium bromide is an aminosteroidal competitive neuromuscular blocker. It does not have significant CV adverse effects or histamine-related effects.
Onset: Dose-dependent: 2.5-3 min.
Duration: Dose-dependent: 30 min-2 hr.
Distribution: Vd: 0.25 L/kg.
Metabolism: Converted to 3-desacetyl (less active).
Excretion: Via urine (as unchanged); 1.7-2.3 hr (elimination half-life).
ATC Classification
 M03AC06 - pipecuronium bromide ; Belongs to the class of other quaternary ammonium-containing agents used as peripherally-acting muscle relaxants.
Available As
  • Pipecuronium 2 mg
  • Pipecuronium 5 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Pipecuronium


    Pipecuronium Containing Brands

    We are Developing Our database, More results coming soon.

    Pipecuronium is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Pipecuronium

    We are Developing Our database, More results coming soon.