Indications |
Oral Uncomplicated gonorrhoea Adult: 800 mg as a single daily dose.
Oral Chronic bacterial prostatitis Adult: 400 mg bid for 28 days.
Oral Complicated urinary tract infections Adult: 400 mg bid for 10-21 days.
Oral Chronic relapsing urinary tract infections Adult: 400 mg bid for up to 12 wk, may be reduced to 400 mg once daily if adequate suppression within first 4 wk.
Oral Gastroenteritis Adult: 400 mg bid for 3-5 days
Oral Uncomplicated urinary tract infections Adult: Infections caused by susceptible Escherichia coli, Klebsiella pneumoniae, roteus mirabilis species: 400 mg bid for 3 days. Infections caused by other susceptible bacteria: 400 mg bid for 7-10 days.
Ophthalmic Conjunctivitis Adult: As 0.3% solution: Usual dose, 1 or 2 drops in the eye 4 times daily for up to 7 days. Dosage may be increased to 1 or 2 drops every 2 hr for the 1st day in more severe infections. Child: ≥1 yr, as 0.3% solution: Usual dose, 1 or 2 drops in the eye 4 times daily for up to 7 days. Dosage may be increased to 1 or 2 drops every 2 hr for the 1st day in more severe infections. Special Populations: Reduce dose in patients with renal impairment: CrCl: ≤30 mL/min: 400 mg once daily. |
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Contraindications |
Hypersensitivity to quinolones; children <18 yr. Lactation. | ||||||||||||||||||||||||
Warnings / Precautions |
Renal impairment; history of CNS disorders; myasthaenia gravis. Pregnancy. QT prolongation; discontinue if signs of neuropathy occur. | ||||||||||||||||||||||||
Adverse Reactions |
Nausea, vomiting, heartburn, constipation, diarrhoea, abdominal cramping, anorexia; headache, dizziness; depression, insomnia; phototoxicity; rash, fever, arthralgia; elevated liver enzymes, urea and creatinine. Eosinophilia, neutropenia, thrombocytopenia and anaemia; hyperhidris; tendon rupture; QT prolongation. Potentially Fatal: Anaphylaxis, acute renal failure, seizures. |
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Overdose Reactions |
Empty stomch by vomiting or gastric lavage. Give symptomatic and supportive treatment. | ||||||||||||||||||||||||
Drug Interactions |
Antacids reduce absorption from GI tract. Probenecid reduces urinary excretion of norfloxacin. Norfloxacin may increase concentration of clozapine, ropinirole, tacrine, tizanidine. Severe hypoglycaemia has occured rarely with glyburide. Increased risk of CNS stimulation and seizures with NSAIDs. Potentially Fatal: Raises theophylline and ciclosporin levels. Effects of warfarin potentiated. Risk of QT prolongation and torsades de pointes with class I and III antiarrythmics, cisapride, erythromycin, antipsychotics, TCAs. See Below for More norfloxacin Drug Interactions |
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Food Interactions |
Absorption reduced, especially when taken with dairy products e.g. milk or yogurt. | ||||||||||||||||||||||||
Mechanism of Actions |
Norfloxacin inhibits the action of DNA gyrase in DNA replication, transcription, repair, recombination and transposition. Absorption: 30-40% absorbed from the GI tract (oral); peak plasma concentrations after 1-2 hr. May be delayed by the presence of food. Distribution: Genitourinary tract, placenta, bile (high concentrations). Protein-binding: 14%. Metabolism: Hepatic; converted to several metabolites with antibacterial activity. Excretion: Via urine by glomerular filtration and tubular secretion within 24 hr (30% as unchanged); via faeces (30%); 4 hr (elimination half-life); may be prolonged in renal impairment. |
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Administration |
Should be taken on an empty stomach. (Take on an empty stomach 1 hr before or 2 hr after meals, w/ a glass of water. Ensure adequate hydration. Do not take w/ dairy products.) |
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Storage Conditions |
Ophthalmic: Store at 15-30°C. Oral: Store at 15-30°C. | ||||||||||||||||||||||||
ATC Classification |
J01MA06 - norfloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections. S01AX12 - norfloxacin ; Belongs to the class of other antiinfectives. Used in the treatment of eye infections. |
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Storage |
Ophthalmic: Store at 15-30°C. Oral: Store at 15-30°C. | ||||||||||||||||||||||||
Available As |
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Norfloxacin
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Norfloxacin Containing Brands
Norfloxacin is used in following diseases
Drug - Drug Interactions of Norfloxacin
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