Latanoprost

Indications
 Ophthalmic
Ocular hypertension, Open-angle glaucoma
Adult: Instil 1 drop of a 0.005% solution once daily in the evening.
Warnings / Precautions
 Do not use within 5 min of thiomersal-containing preparations. Aphakia or pseudophakia with torn posterior lens cap or anterior chamber lenses; risk factors for cystoid macular oedema; brittle or severe asthma; history of intraocular inflammation; inflammatory, neovascular, angle-closure or congenital glaucoma; pregnancy, lactation. Remove contact lenses during use.
Adverse Reactions
 Brown pigmentation particularly in those with mixed-color irides; blepharitis, ocular irritation and pain; darkening, thickening and lengthening of eyelashes; localised oedema; conjunctival hyperaemia; transient punctate epithelial erosions; dyspnoea; exacerbation of asthma; local skin reactions; iritis; uveitis; darkening of palpebral skin.
Mechanism of Actions
 Latanoprost, a synthetic analogue of prostaglandin F2a, reduces the IOP by increasing the outflow of aqueous humour.
Absorption: Absorbed through the cornea; peak concentration in the aqueous humour is reached around 2 hr after administration.
Metabolism: Rapidly hydrolised to biologically active latanoprost acid by esterases in the cornea.
Excretion: Via urine.
Storage Conditions
 Ophthalmic: Store unopened at 2-8°C and at <25°C for up to 6 wk after opening.
ATC Classification
 S01EE01 - latanoprost ; Belongs to the class of prostaglandin analogues. Used in the treatment of glaucoma.
Storage
 Ophthalmic: Store unopened at 2-8°C and at <25°C for up to 6 wk after opening.
Available As
  • Latanoprost 0.005%
  • Latanoprost 0.005% w/v
  • Latanoprost 50 mcg

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