Lanthanum Carbonate

Indications
 Oral
Hyperphosphataemia in end stage renal failure
Adult: Initially, 0.75-2.25 g daily, given in divided doses wth meals. Dose may be adjusted every 2-3 wk until an acceptable serum phosphate concentration is achieved; usual maintenance dose: 1.5-3 g daily in divided doses. Max: 3.75 g daily.
Warnings / Precautions
 Caution when used in patients with acute peptic ulcer, ulcerative colitis, Crohn's disease or bowel obstruction. Tablets should be thoroughly chewed before swallowing. Pregnancy and lactation.
Adverse Reactions
 GI disturbances, including nausea, vomiting, constipation, diarrhoea, dyspepsia and abdominal pain.
Overdose Reactions
 Supportive treatment is recommended.
Drug Interactions
 Compounds that are known to interact with antacids should not be taken within 2 hr of administering lanthanum carbonate.
See Below for More lanthanum carbonate Drug Interactions
Lab Interactions
 Abdominal x-rays of patients taking lanthanum carbonate may have a radio-opaque appearance typical of an imaging agent.
Mechanism of Actions
 Lanthanum carbonate is a non-calcium, non-aluminium phosphate binder used for hyperphosphataemia in patients with chronic renal failure. It works by inhibiting phosphate absorption by forming highly insoluble lanthanum phosphate complexes, thus reducing both serum phosphate and calcium phosphate product.
Distribution: Highly bound to plasma proteins.
Metabolism: Not metabolised.
Excretion: Eliminated mainly by the biliary system. Elimination half life: Approx 36 hr.
Administration
 Should be taken with food. (Take w/ or immediately after meals. Chew thoroughly before swallowing. Do not swallow whole.)
Storage Conditions
 Oral: Store at 15-30°C.
ATC Classification
 V03AE03 - lanthanum carbonate ; Belongs to the class of drugs used in the treatment of hyperkalemia and hyperphosphatemia.
Storage
 Oral: Store at 15-30°C.
Available As
  • Lanthanum Carbonate 250 mg
  • Lanthanum Carbonate 500 mg

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