Indications |
Oral Management of angina, Heart failure Adult: 20 mg 2-3 times daily. Dose may range from 20-120 mg daily. Elderly: Intiate at lower doses. |
Contraindications |
Severe hypotension or anaemia, hypovolaemia, heart failure due to obstruction, or raised intracranial pressure due to head trauma or cerebral haemorrhage. |
Warnings / Precautions |
Severe renal or severe hepatic impairment, hypothyroidism, malnutrition, or hypothermia. Caution in patients who are already hypotensive. May aggravate angina caused by hypertrophic cardiomyopathy. Tolerance may develop after long-term treatment. Lactation. |
Adverse Reactions |
Hypotension, tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion. Nausea, vomiting, abdominal pain. Restlessness, weakness and vertigo. Dry mouth, chest pain, back pain, oedema, fatigue, abdominal pain, constipation, diarrhoea, dyspepsia and flatulence. Potentially Fatal: Severe hypotension and cardiac failure. |
Overdose Reactions |
Symptoms: Increased intracranial pressure, with or without persistent throbbing headache, confusion and moderate fever, vertigo, palpitations, visual disturbances, nausea and vomiting. |
Drug Interactions |
Hypotensive effects may be increased when used with alcohol or vasodilators. Concurrent use with calcium channel blockers may lead to marked orthostatic hypotension. Potentially Fatal: Significant hypotension may occur when used with phosphodiesterase-5 inhibitors. See Below for More isosorbide mononitrate Drug Interactions |
Lab Interactions |
False decrease in serum cholesterol. |
Mechanism of Actions |
Isosorbide mononitrate relaxes vascular smooth muscles by stimulating cyclic-GMP. It decreases left ventricular pressure (preload) and arterial resistance (afterload). Onset: 20 min (oral as conventional tab). Duration: 8-10 hr (oral as conventional tab). Absorption: Readily absorbed from the GIT (oral); peak plasma concentrations after 1 hr. Distribution: Widely distributed: Smooth muscle cells of the blood vessels. Metabolism: Converted to inactive metabolites including isosorbide and isosorbide glucuronide. Excretion: Via urine (2% as unchanged); 4-5 hr (elimination half-life). |
Administration |
Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food). |
Storage Conditions |
Oral: Store at 20-25°C. |
ATC Classification |
C01DA14 - isosorbide mononitrate ; Belongs to the class of organic nitrate vasodilators. Used in the treatment of cardiac disease. |
Storage |
Oral: Store at 20-25°C. |
Available As |
|
Isosorbide 5 Mononitrate
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Isosorbide 5 Mononitrate Containing Brands
Isosorbide 5 Mononitrate is used in following diseases
Drug - Drug Interactions of Isosorbide 5 Mononitrate
Isosorbide-5 Mononitrate
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Post Review about Isosorbide-5 Mononitrate Click here to cancel reply.
Isosorbide-5 Mononitrate Containing Brands
Isosorbide-5 Mononitrate is used in following diseases
Drug - Drug Interactions of Isosorbide-5 Mononitrate
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