Indications |
Parenteral Severe hypoglycaemia Adult: 1 mg (0.5 mg for patients <25 kg) given as SC, IM or IV. If no response within 10 minutes, then IV glucose should be given. Glucagon dose may be repeated if necessary. Parenteral As a diagnostic aid in the radiologic examination of the gastrointestinal tract Adult: 1-2 mg IM or 0.2-2 mg IV inj. |
Contraindications |
Phaeochromocytoma; hypersensitivity. |
Warnings / Precautions |
Ineffective in chronic hypoglycaemia, alcohol-induced hypoglycaemia, starvation and adrenal insufficiency; diagnostic aid in diabetic patients or in elderly with heart disease. Insulinoma; glucagonoma. Monitor prothrombin time and adjust oral anticoagulant dosage. Pregnancy. |
Adverse Reactions |
Nausea, vomiting, diarrhoea. Potentially Fatal: Hypokalaemia. |
Drug Interactions |
May enhance anticoagulant effect of oral anticoagulants e.g. warfarin. See Below for More glucagon Drug Interactions |
Mechanism of Actions |
Glucagon is a polypeptide that is produced by α cells of islets of Langerhans in the pancreas. It acts by stimulating adenylate cyclase to produce cAMP thus promoting hepatic glycogenolysis and gluconeogenesis causing an increase in blood-glucose levels. Onset: 5-20 minutes (IV); 30 minutes (IM); 30-45 minutes (SC). Duration: 30 minutes (IV); 60-90 minutes (SC). Metabolism: Mainly hepatic; some inactivation in kidneys and plasma. Excretion: 8-18 minutes (plasma half-life). |
Storage Conditions |
Parenteral: Store at 20-25°C. |
ATC Classification |
H04AA01 - glucagon ; Belongs to the class of glycogenolytic hormones. Used in the treatment of hypoglycemia. |
Storage |
Parenteral: Store at 20-25°C. |
Available As |
|
Glucagon
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Glucagon Containing Brands
Glucagon is used in following diseases
Drug - Drug Interactions of Glucagon
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