Indications |
Oral Pain and inflammation associated with musculoskeletal and joint disorders Adult: 150-200 mg daily in divided doses, increased to 300 mg daily in acute or severe conditions if necessary. Oral Dysmenorrhoea Adult: Initially, 100 mg followed by 50-100 mg every 4-6 hr. Max: 300 mg/day. Oral Sore throat Adult: 1 lozenge (8.75 mg) every 3-6 hr. Max: 5 lozenges/day. Max treatment duration: 3 days. Child: <12 yr: Not recommended. Ophthalmic Prophylaxis of miosis during ocular surgery Adult: As sodium: Instill 1 drop of a 0.03% solution into the eye every 30 minutes starting 2 hr before and ending not < 30 minutes before the surgery. Ophthalmic Postoperative ocular inflammation Adult: Instill 1 drop of a 0.03% solution into the eye 4 times daily for 1-3 wk starting at 24 hr after surgery. |
Contraindications |
Peptic ulcer, GI haemorrhage, asthma, bronchospasm, rhinitis, angioedema, hypersensitivity; aspirin intolerance; pregnancy (3rd trimester); lactation. |
Warnings / Precautions |
Hypertension; impaired renal function. |
Adverse Reactions |
Fluid retention, oedema; allergic nephritis, allergic reactions; GI upsets; dizziness, tinnitus, blurring of vision; local irritation, transient burning and stinging (ophthalmic). Potentially Fatal: Peptic ulceration, haemorrhage and perforation. |
Drug Interactions |
Increases serum concentrations of digoxin; may enhance effects of anticoagulants. See Below for More flurbiprofen Drug Interactions |
Mechanism of Actions |
Flurbiprofen inhibits prostaglandin synthesis by decreasing the activity of cyclooxygenase resulting in reduced prostaglandin levels. It is also a potent inhibitor of platelet aggregation. Onset: 1-2 hrs. Absorption: Readily absorbed from the GIT (oral); peak plasma concentrations after 1-2 hrs. Distribution: Small amounts enter breast milk. Protein-binding: 99% Metabolism: Hepatic via hydroxylation and conjugation. Excretion: Urine (as metabolites); 3-6 hrs (elimination half-life). |
Administration |
Should be taken with food. |
Storage Conditions |
Ophthalmic: Store at 15-25°C. Oral: Store at 15-25°C. |
ATC Classification |
M01AE09 - flurbiprofen ; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products. M02AA19 - flurbiprofen ; Belongs to the class of non-steroidal antiinflammatory preparations for topical use. Used in the treatment of joint and muscular pains. S01BC04 - flurbiprofen ; Belongs to the class of non-steroidal antiinflammatory agents. Used in the treatment of inflammation of the eye. |
Storage |
Ophthalmic: Store at 15-25°C. Oral: Store at 15-25°C. |
Available As |
|
Flurbiprofen
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Flurbiprofen Containing Brands
Flurbiprofen is used in following diseases
Drug - Drug Interactions of Flurbiprofen
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