Codergocrine Mesylate

Indications
 Oral
Mild to moderate dementia
Adult: 3-4.5 mg daily. May also be given via sublingual admin.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Pregnancy. Severe bradycardia.
Adverse Reactions
 Abdominal cramps, nausea, vomiting, headache, blurred vision, skin rashes, nasal congestion, flushing of the skin, dizziness, orthostatic hypotension, bradycardia.
Mechanism of Actions
 Co-dergocrine mesylate is a complex of 4 hydrogenated ergot alkaloids.It acts at the central synapsi causing dopaminergic and serotonergic actions while reducing noradrenergic activity in the limbic and other areas. Age-related symptoms and signs such as loss of recent memory, confusion, poor concentration, disorientation, apathy, depression, difficulty in self-care and unsociability are improved.
Absorption: Oral: Rapidly absorbed from the GI tract; plasma levels peak about 1-2 hr after a dose.
Distribution: 81% bound to plasma proteins.
Metabolism: Extensive first-pass effect.
Excretion: Mainly in bile via the faeces, via urine (small amounts); elimination T1/2 (biphasic): 1.5-2.5 hr (α-phase), 13-15 hr (β-phase).
Storage Conditions
 Oral: Store below 25°C.
ATC Classification
 C04AE04 - dihydroergocristine ; Belongs to the class of ergot alkaloids. Used as peripheral vasodilators.
Storage
 Oral: Store below 25°C.
Available As
  • Codergocrine Mesylate 0.3 mg
  • Codergocrine Mesylate 1 mg

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