Ceftibuten

Indications
 Oral
Respiratory tract infections, Urinary tract infections
Adult: As dihydrate: 400 mg once daily.
Child: >6 mth and ≤45 kg: 9 mg/kg/day as a single dose.
CrCl (ml/min)Dosage Recommendation
30-49200 mg once daily.
5-29100 mg once daily.


Special Populations: Moderate to severe renal impairment: CrCl 30-49 mL/min: 200 mg once daily; 5-29 mL/min: 100 mg once daily.
Contraindications
 Hypersensitivity to cephalosporins.
Warnings / Precautions
 Hypersensitivity to penicillins; renal impairment; Porphyria. Monitor renal and haematologic status.
Adverse Reactions
 Nausea; vomiting; diarrhoea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; hepatic dysfunction; haematologic disorders; pain at Inj site (IM); thrombophloebitis (IV infusion); superinfection with prolonged use. Headache.
Potentially Fatal: Pseudomembranous colitis.
Drug Interactions
 Renal excretion inhibited by probenecid. Bacteriostatic antibacterials.
Potentially Fatal: Nephrotoxic drug eg. aminoglycoside may increase risk of kidney damage. Enhanced nephrotoxicity with a loop diuretic.
See Below for More ceftibuten Drug Interactions
Lab Interactions
 Positive direct antiglobulin Coombs' test; falsely high values with Jaffe method of measuring creatinine concentrations; +ve reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
Mechanism of Actions
 Ceftibuten inhibits bacterial cell wall synthesis. It is stable to hydrolysis by many β-lactamases and has greater activity than 1st or 2nd generation cephalosporins against gm-ve bacteria. It is less active in vitro than cefexime against S. pneumoniae.
Absorption: Rapidly absorbed from the GI tract after oral admin.
Distribution: 65-77% bound to plasma proteins.
Excretion: Plasma half-life: 2.0-2.3 hr; prolonged in renal impairment. Mainly in the urine and faeces.
Administration
 Cap: May be taken with or without food.
Susp: Should be taken on an empty stomach. (Take 2 hr before or 1 hr after meals.)
ATC Classification
 J01DD14 - ceftibuten ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Available As
  • Ceftibuten 400 mg
  • Ceftibuten 90 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Ceftibuten


    Ceftibuten Containing Brands

    We are Developing Our database, More results coming soon.

    Ceftibuten is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Ceftibuten

    We are Developing Our database, More results coming soon.