Cefoperazone

Indications
 Parenteral
Susceptible infections
Adult: As sodium: 2-4 g daily in 2 divided doses, increased to 12 g daily in 2-4 divided doses for severe infections given as deep IM or IV infusion.
Renal impairment: With liver impairment: 1-2 g daily.
Hepatic impairment: Max dose for liver impairment or biliary obstruction: 4 g daily.

Special Populations: Max dose for liver impairment or biliary obstruction: 4 g daily; liver and kidney impairment: 1-2 g daily.
Contraindications
 Hypersensitivity to cephalosporin.
Warnings / Precautions
 History of penicillin allergy; renal or hepatic impairment; pregnancy, lactation; cystic fibrosis.
Adverse Reactions
 Skin rash, urticaria; eosinophilia, diarrhoea, nausea, vomiting; phloebitis; hypoprothrombinaemia; superinfection.
Potentially Fatal: Neuromuscular hypersensitivity; nephrotoxicity.
Drug Interactions
 Disulfiram-like reaction with alcohol. Potentiates anticoagulants.
Potentially Fatal: Enhances nephrotoxicity by aminoglycosides and furosemide.
See Below for More cefoperazone Drug Interactions
Mechanism of Actions
 Cefoperazone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Distribution: Widely distributed into body tissues and fluids; poor CSF penetration. Crosses the placenta and enters breast milk (low concentrations); bile (high concentrations). Protein-binding: 82-93%
Excretion: Mainly via the bile. Via the urine within 12-24 hrs by glomerular filtration (30% as unchanged); proportion may be increased in hepatic or biliary disease.
Storage Conditions
 Parenteral: Store below 25°C.
ATC Classification
 J01DD12 - cefoperazone ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Storage
 Parenteral: Store below 25°C.
Available As
  • Cefoperazone Sodium 1000 mg
  • Cefoperazone 1000 mg
  • Cefoperazone Sodium 125 mg
  • Cefoperazone 125 mg
  • Cefoperazone 2000 mg
  • Cefoperazone Sodium 2000 mg
  • Cefoperazone Sodium 250 mg
  • Cefoperazone 250 mg
  • Cefoperazone 500 mg
  • Cefoperazone Sodium 500 mg
  • Cefoperazone 750 mg

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