Indications |
Oral Echinococcosis Adult: >60 kg: 400 mg bid for 28 days; <60 kg: 15 mg/kg daily in 2 divided doses. Max dose: 800 mg daily. For cystic echinococcosis, up to 3 treatment cycles of 28 days each may be given with 14 treatment-free days in between cycles. For alveolar echinococcosis, treatment cycles of 28 days each with 14 treatment-free days in between. Treatment cycles may need to be continued for mth or yr until complete eradication of parasites. Oral Neurocysticercosis Adult: >60 kg: 400 mg bid; <60 kg: 15 mg/kg daily in 2 divided doses for 8-30 days. Max Dosage: Adult <60 kg: 800 mg daily. Oral Enterobiasis Adult: 400 mg as a single dose. Child: ≥2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose for enterobiasis. Oral Ascariasis Adult: 400 mg as a single dose. Child: ≥2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose for enterobiasis. Oral Hookworm infections Adult: 400 mg as a single dose. Child: ≥2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose for enterobiasis. Oral Strongyloidiasis Adult: 400 mg once daily or bid for 3 consecutive days, repeated after 3 wk if necessary. Oral Giardiasis Adult: 400 mg daily for 5 days. Child: 400 mg daily for 5 days. |
Contraindications |
Pregnancy and lactation. Neonates. Hypersensitivity, liver impairment. |
Warnings / Precautions |
Monitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease. |
Adverse Reactions |
GI discomfort, headache, nausea, dizziness, allergic reactions, pruritus, raised liver enzymes, alopecia and dry mouth. Potentially Fatal: Bone marrow depression. |
Overdose Reactions |
Symptomatic and supportive measures are advised. |
Drug Interactions |
Cimetidine increases albendazole metabolism. Serum levels are increased if taken with dexamethasone and praziquantel agent. See Below for More albendazole Drug Interactions |
Mechanism of Actions |
Albendazole exhibits a broad-spectrum anthelmintic activity showing vermicidal, ovicidal and larvicidal actions. It inhibits tubulin polymerization in the parasite and blocks glucose uptake; energy levels are reduced resulting to death of the parasite. Susceptible parasites include hookworm, roundworm, threadworm, whipworm, tapeworm, strongyloides, opisthorchis and hydatid disease (Echinococcus). Absorption: Poorly absorbed from the GI tract (oral). Distribution: Widely distributed; bile, CSF. Protein-binding: 70% Metabolism: Extensive hepatic first-pass metabolism; converted to albendazole sulfoxide. Excretion: Via bile; via urine (small amounts). 8.5 hr (elimination half-life). |
Administration |
Should be taken with food. |
Storage Conditions |
Oral: Store at 20-25°C. |
ATC Classification |
P02CA03 - albendazole ; Belongs to the class of benzimidazole derivative agents. Used as antinematodal. |
Storage |
Oral: Store at 20-25°C. |
Available As |
|
Albendazole
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Albendazole is used in following diseases
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