Trimethoprim vs Amantadine

Interacting Drugs
Trimethoprim
vs
Amantadine
Security Level
Minor, Monitor Therapy
Mechanism
Amantadine: Trimethoprim may enhance the adverse/toxic effect of Amantadine. Specifically, the risk of myoclonus and/or delirium may be increased. Trimethoprim may increase the serum concentration of Amantadine. Amantadine may increase the serum concentration of Trimethoprim.
Management
Monitor therapy

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