Topical cocaine vs Tamoxifen

Interacting Drugs
Topical cocaine
vs
Tamoxifen
Security Level
Major, Avoid combination
Mechanism
Tamoxifen: CYP2D6 Inhibitors (Strong) may decrease the metabolism of Tamoxifen. Specifically, strong CYP2D6 inhibitors may decrease the formation of highly potent active metabolites.
Management
Avoid combination

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