Tolbutamide vs Leflunomide

Interacting Drugs
Tolbutamide
vs
Leflunomide
Security Level
Minor, Monitor Therapy
Mechanism
Leflunomide: TOLBUTamide may increase the serum concentration of Leflunomide. Specifically, tolbutamide may increase the proportion of non-protein-bound (i.e., free fraction) M1, which is the active metabolite of leflunomide. Leflunomide may increase the serum concentration of TOLBUTamide. Specifically, the active metabolite of leflunomide (M1) may both increase total tolbutamide concentrations and increase the free fraction (i.e., non-protein bound) of tolbutamide.
Management
Monitor therapy

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Other Interactions of Tolbutamide

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Other Interactions of Leflunomide

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