Interacting Drugs |
Tolbutamide vs Leflunomide |
Security Level |
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Mechanism |
Leflunomide: TOLBUTamide may increase the serum concentration of Leflunomide. Specifically, tolbutamide may increase the proportion of non-protein-bound (i.e., free fraction) M1, which is the active metabolite of leflunomide. Leflunomide may increase the serum concentration of TOLBUTamide. Specifically, the active metabolite of leflunomide (M1) may both increase total tolbutamide concentrations and increase the free fraction (i.e., non-protein bound) of tolbutamide. |
Management |
Monitor therapy |
Tolbutamide vs Leflunomide
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Other Interactions of Tolbutamide
Other Interactions of Leflunomide
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