Temsirolimus vs Protease Inhibitors

Interacting Drugs
Temsirolimus
vs
Protease Inhibitors
Security Level
Moderate, Consider therapy modification
Mechanism
Protease Inhibitors: May enhance the adverse/toxic effect of Temsirolimus. Levels of sirolimus, the active metabolite, may be increased, likely due to inhibition of CYP-mediated metabolism.
Management
Consider therapy modification

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