Temsirolimus vs Phenytoin

Interacting Drugs
Temsirolimus
vs
Phenytoin
Security Level
Moderate, Consider therapy modification
Mechanism
Phenytoin: May decrease the serum concentration of Temsirolimus. Concentrations of the active metabolite, sirolimus, are also likely to be decreased (and maybe to an even greater degree).
Management
Temsirolimus prescribing information recommends against coadministration with strong CYP3A4 inducers such as phenytoin; however, if concurrent therapy is necessary, an increase in temsirolimus adult dose to 50 mg/week should be considered.

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