Temsirolimus vs Itraconazole

Interacting Drugs
Temsirolimus
vs
Itraconazole
Security Level
Moderate, Consider therapy modification
Mechanism
Itraconazole: May increase serum concentrations of the active metabolite(s) of Temsirolimus.
Management
Consider temsirolimus dose reductions or alternatives to itraconazole. Monitor sirolimus concentrations in all patients receiving itraconazole or any systemic azole antifungal.

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