Interacting Drugs |
Temsirolimus vs CarBAMazepine |
Security Level |
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Mechanism |
CarBAMazepine: May decrease the serum concentration of Temsirolimus. Concentrations of the active metabolite, sirolimus, are also likely to be decreased (and maybe to an even greater degree). |
Management |
Temsirolimus prescribing information recommends against coadministration with strong CYP3A4 inducers such as carbamazepine; however, if concurrent therapy is necessary, an increase in temsirolimus adult dose to 50 mg/week should be considered. |
Temsirolimus vs CarBAMazepine
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Other Interactions of CarBAMazepine
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