Spiramycin vs Etravirine

Interacting Drugs
Spiramycin
vs
Etravirine
Mechanism
Etravirine: May decrease the serum concentration of Macrolide Antibiotics. Clarithromycin AUC is reduced and levels of the active metabolite (14-hydroxy-clarithromycin) are modestly increased.
Management
For the treatment of complex, consider changing to alternative agent, such as azithromycin.

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