Interacting Drugs |
Sirolimus vs Tacrolimus |
Security Level |
|
Mechanism |
Tacrolimus: May enhance the adverse/toxic effect of Sirolimus. Sirolimus may enhance the adverse/toxic effect of Tacrolimus. Sirolimus may decrease the serum concentration of Tacrolimus. |
Management |
Tacrolimus and sirolimus should only be used concomitantly as part of a protocol with a known risk:benefit profile and an established safety record. Several regimens combining these agents have been associated with excess morbidity and/or mortality. |
Sirolimus vs Tacrolimus
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Other Interactions of Sirolimus
Other Interactions of Tacrolimus
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