Sirolimus vs Tacrolimus

Interacting Drugs
Sirolimus
vs
Tacrolimus
Security Level
Moderate, Consider therapy modification
Mechanism
Tacrolimus: May enhance the adverse/toxic effect of Sirolimus. Sirolimus may enhance the adverse/toxic effect of Tacrolimus. Sirolimus may decrease the serum concentration of Tacrolimus.
Management
Tacrolimus and sirolimus should only be used concomitantly as part of a protocol with a known risk:benefit profile and an established safety record. Several regimens combining these agents have been associated with excess morbidity and/or mortality.

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Other Interactions of Tacrolimus

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