Sirolimus vs Tacrolimus (Systemic)

Interacting Drugs
Sirolimus
vs
Tacrolimus (Systemic)
Security Level
Major, Avoid combination
Mechanism
Tacrolimus (Systemic): May enhance the adverse/toxic effect of Sirolimus. Sirolimus may enhance the adverse/toxic effect of Tacrolimus (Systemic). Sirolimus may decrease the serum concentration of Tacrolimus (Systemic).
Management
Avoid combination

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