Sirolimus vs Efavirenz

Interacting Drugs
Sirolimus
vs
Efavirenz
Security Level
Moderate, Consider therapy modification
Mechanism
Efavirenz: May decrease the serum concentration of Sirolimus.
Management
Closely monitor sirolimus serum concentrations when starting, stopping, or changing doses of efavirenz, particularly during the first 2 weeks after any change. Dose adjustment of sirolimus may be required.

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