Sirolimus vs CycloSPORINE

Interacting Drugs
Sirolimus
vs
CycloSPORINE
Security Level
Moderate, Consider therapy modification
Mechanism
CycloSPORINE: Sirolimus may enhance the adverse/toxic effect of CycloSPORINE. An increased risk of calcineurin inhibitor-induced hemolytic uremic syndrome/thrombotic thrombocytopenic purpura/thrombotic microangiopathy (HUS/TTP/TMA) has been described. CycloSPORINE may increase the serum concentration of Sirolimus. This is of specific concern with cyclosporine [MODIFIED].
Management
Administer oral doses of sirolimus 4 hours after doses of cyclosporine. Monitor for toxic effects of sirolimus if used with cyclosporine.

Subscribe for latest updates

Subscribe to our e-mail newsletter to receive updates.

No comments yet.

Post Review about Sirolimus vs CycloSPORINE


Other Interactions of Sirolimus

We are Developing Our database, More results coming soon.