Salsalate vs NSAID (Nonselective)

Interacting Drugs
Salsalate
vs
NSAID (Nonselective)
Security Level
Moderate, Consider therapy modification
Mechanism
NSAID (Nonselective): May enhance the adverse/toxic effect of Salicylates. An increased risk of bleeding may be associated with use of this combination. NSAID (Nonselective) may diminish the cardioprotective effect of Salicylates. Salicylates may decrease the serum concentration of NSAID (Nonselective). Exceptions: Diclofenac.
Management
Consider therapy modification

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