Salsalate vs Drotrecogin Alfa

Interacting Drugs
Drotrecogin Alfa
Security Level
Moderate, Consider therapy modification
Drotrecogin Alfa: Salicylates may enhance the adverse/toxic effect of Drotrecogin Alfa. Bleeding may occur.
Weigh potential benefits of drotrecogin against increased bleeding risk in patients who have received platelet inhibitors including aspirin (over 650 mg daily within 1 week). Monitor for bleeding and stop infusion if clinically important bleeding occurs.

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