Salsalate vs Drotrecogin Alfa

Interacting Drugs
Salsalate
vs
Drotrecogin Alfa
Security Level
Moderate, Consider therapy modification
Mechanism
Drotrecogin Alfa: Salicylates may enhance the adverse/toxic effect of Drotrecogin Alfa. Bleeding may occur.
Management
Weigh potential benefits of drotrecogin against increased bleeding risk in patients who have received platelet inhibitors including aspirin (over 650 mg daily within 1 week). Monitor for bleeding and stop infusion if clinically important bleeding occurs.

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