Rufinamide vs Divalproex

Interacting Drugs
Rufinamide
vs
Divalproex
Security Level
Moderate, Consider therapy modification
Mechanism
Divalproex: May increase the serum concentration of Rufinamide.
Management
Initiate rufinamide at a dose less than 10 mg/kg/day (children) or 400 mg/day (adults) in patients receiving divalproex. In patients receiving rufinamide, initiate divalproex at a low dose and titrate based on clinical response.

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Other Interactions of Rufinamide

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Other Interactions of Divalproex

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