Rosuvastatin vs Gemfibrozil

Interacting Drugs
Rosuvastatin
vs
Gemfibrozil
Security Level
Moderate, Consider therapy modification
Mechanism
Gemfibrozil: May enhance the myopathic (rhabdomyolysis) effect of Rosuvastatin. Gemfibrozil may increase the serum concentration of Rosuvastatin.
Management
If possible, avoid concomitant use of rosuvastatin with gemfibrozil. If concomitant can not be avoided, limit rosuvastatin to 10 mg/day (US recommendation) or 20 mg/day (Canadian recommendation). Monitor for signs/symptoms of rhabdomyolysis.

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Other Interactions of Gemfibrozil

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