Rifampin and isoniazid vs Dabigatran Etexilate

Interacting Drugs
Rifampin and isoniazid
vs
Dabigatran Etexilate
Security Level
Major, Avoid combination
Mechanism
Dabigatran Etexilate: P-glycoprotein/ABCB1 Inducers may decrease the serum concentration of Dabigatran Etexilate.
Management
Avoid concurrent use of dabigatran with a p-glycoprotein inducer when possible. Closely monitor for decreased levels/effects of dabigatran if concomitantly administering a p-glycoprotein inducer, particularly strong inducers.

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