Rifampin and isoniazid vs Contraceptives (Progestins)

Interacting Drugs
Rifampin and isoniazid
vs
Contraceptives (Progestins)
Security Level
Moderate, Consider therapy modification
Mechanism
Contraceptives (Progestins): Rifamycin Derivatives may decrease the serum concentration of Contraceptives (Progestins). Contraceptive failure is possible.
Management
Contraceptive failure is possible. Use of an alternative, nonhormonal contraceptive is recommended.

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