Rifampin and isoniazid vs Calcium Channel Blockers

Interacting Drugs
Rifampin and isoniazid
vs
Calcium Channel Blockers
Security Level
Moderate, Consider therapy modification
Mechanism
Calcium Channel Blockers: Rifamycin Derivatives may increase the metabolism of Calcium Channel Blockers. This primarily affects oral forms of calcium channel blockers.
Management
The labeling for some U.S. and Canadian calcium channel blockers contraindicate use with rifampin however recommendations vary. Consult appropriate labeling. Exceptions: Clevidipine.

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