Ranitidine vs Itraconazole

Interacting Drugs
Ranitidine
vs
Itraconazole
Security Level
Moderate, Consider therapy modification
Mechanism
Itraconazole: H2-Antagonists may decrease the serum concentration of Itraconazole.
Management
When this combination is used, the itraconazole should be administered with a cola beverage (8 ounces). Itraconazole oral suspension may be less sensitive to this interaction. Monitor patient response to itraconazole closely.

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