Promethazine, phenylephrine, and codeine vs Sibutramine

Interacting Drugs
Promethazine, phenylephrine, and codeine
vs
Sibutramine
Security Level
Major, Avoid combination
Mechanism
Sibutramine: May enhance the serotonergic effect of Serotonin Modulators. This may cause serotonin syndrome.
Management
Avoid combination

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