Promethazine, phenylephrine, and codeine vs Droperidol

Interacting Drugs
Promethazine, phenylephrine, and codeine
vs
Droperidol
Security Level
Moderate, Consider therapy modification
Mechanism
Droperidol: May enhance the CNS depressant effect of CNS Depressants.
Management
Consider dose reductions of droperidol or of other CNS agents (e.g., opioids, barbiturates) with concomitant use.

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