Phenobarbital vs Lopinavir

Interacting Drugs
Phenobarbital
vs
Lopinavir
Security Level
Moderate, Consider therapy modification
Mechanism
Lopinavir: PHENobarbital may decrease the serum concentration of Lopinavir.
Management
Increased doses of lopinavir may be necessary when using these agents in combination. Do not use a once daily lopinavir/ritonavir regimen together with phenobarbital. Increase monitoring of therapeutic response in all patients using this combination.

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