Phenobarbital vs Linagliptin

Interacting Drugs
Phenobarbital
vs
Linagliptin
Security Level
Moderate, Consider therapy modification
Mechanism
Linagliptin: CYP3A4 Inducers (Strong) may decrease the serum concentration of Linagliptin.
Management
Strongly consider using an alternative to any strong CYP3A4 inducer in patients who are being treated with linagliptin. If this combination is used, monitor patients closely for evidence of reduced linagliptin effectiveness.

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