Phenobarbital vs Ixabepilone

Interacting Drugs
Phenobarbital
vs
Ixabepilone
Security Level
Moderate, Consider therapy modification
Mechanism
Ixabepilone: CYP3A4 Inducers (Strong) may decrease the serum concentration of Ixabepilone.
Management
Avoid this combination whenever possible. If this combination must be used, a gradual increase in ixabepilone dose from 40 mg/m2 to 60 mg/m2 (given as a 4-hour infusion), as tolerated, should be considered.

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