Phenobarbital vs Imatinib

Interacting Drugs
Phenobarbital
vs
Imatinib
Security Level
Moderate, Consider therapy modification
Mechanism
Imatinib: CYP3A4 Inducers (Strong) may decrease the serum concentration of Imatinib.
Management
Avoid concurrent use of imatinib with strong CYP3A4 inducers when possible. If such a combination must be used, increase imatinib dose by at least 50% and monitor the patient's clinical response closely.

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