Phenobarbital vs Felbamate

Interacting Drugs
Phenobarbital
vs
Felbamate
Security Level
Minor, Monitor Therapy
Mechanism
Felbamate: May increase the serum concentration of Barbiturates. Barbiturates may decrease the serum concentration of Felbamate.
Management
Monitor for elevated barbiturate concentrations/toxicity if felbamate is initiated/dose increased, or reduced concentrations/effects if felbamate is discontinued/dose decreased. Refer to phenobarbital dosing guidelines for patients receiving that agent.

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Phenobarbital vs Felbamate

Interacting Drugs
Phenobarbital
vs
Felbamate
Security Level
Moderate, Consider therapy modification
Mechanism
Felbamate: PHENobarbital may decrease the serum concentration of Felbamate. Felbamate may increase the serum concentration of PHENobarbital.
Management
In patients receiving phenobarbital, initiate felbamate at 1200 mg/day in divided doses 3-4 times daily and reduce phenobarbital dose by 20%. Monitor for increased phenobarbital concentrations/effects and decreased felbamate concentrations/effects.

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