Phenobarbital vs Everolimus

Interacting Drugs
Phenobarbital
vs
Everolimus
Security Level
Major, Avoid combination
Mechanism
Everolimus: CYP3A4 Inducers (Strong) may decrease the serum concentration of Everolimus.
Management
Avoid concurrent use of strong CYP3A4 inducers, but if strong CYP3A4 inducers cannot be avoided, consider gradually (in 5 mg increments) increasing the everolimus dose from 10 mg/day to 20 mg/day (adult doses).

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Other Interactions of Everolimus

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