Pemetrexed vs NSAID (Nonselective)

Interacting Drugs
Pemetrexed
vs
NSAID (Nonselective)
Security Level
Moderate, Consider therapy modification
Mechanism
NSAID (Nonselective): May increase the serum concentration of PEMEtrexed.
Management
Patients with mild-to-moderate renal insufficiency (CrCl 45-79 mL/minute) may use ibuprofen with caution, but should avoid other NSAIDs for 2-5 days prior to, the day of, and 2 days after pemetrexed.

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