Paregoric vs Mixed Agonist / Antagonist Opioids

Interacting Drugs
Paregoric
vs
Mixed Agonist / Antagonist Opioids
Security Level
Moderate, Consider therapy modification
Mechanism
Mixed Agonist / Antagonist Opioids: May diminish the analgesic effect of Analgesics (Opioid).
Management
Seek alternatives to mixed agonist/antagonist opioids in patients receiving pure opioid agonists, and monitor for symptoms of therapeutic failure/high dose requirements (or withdrawal in opioid-dependent patients) if patients receive these combinations.

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