Paregoric vs Alvimopan

Interacting Drugs
Paregoric
vs
Alvimopan
Security Level
Moderate, Consider therapy modification
Mechanism
Alvimopan: Analgesics (Opioid) may enhance the adverse/toxic effect of Alvimopan. This is most notable for patients receiving long-term (i.e., more than 7 days) opiates prior to alvimopan initiation.
Management
Alvimopan is contraindicated in patients receiving therapeutic doses of opioids for more than 7 consecutive days immediately prior to alvimopan initiation.

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