Orphenadrine, aspirin, and caffeine vs Methotrexate

Interacting Drugs
Orphenadrine, aspirin, and caffeine
vs
Methotrexate
Security Level
Moderate, Consider therapy modification
Mechanism
Methotrexate: Salicylates may increase the serum concentration of Methotrexate. Salicylate doses used for prophylaxis of cardiovascular events are not likely to be of concern.
Management
Consider therapy modification

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Other Interactions of Methotrexate

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