Omeprazole and sodium bicarbonate vs Cilostazol

Interacting Drugs
Omeprazole and sodium bicarbonate
vs
Cilostazol
Security Level
Moderate, Consider therapy modification
Mechanism
Cilostazol: Omeprazole may enhance the adverse/toxic effect of Cilostazol. Omeprazole may increase the serum concentration of Cilostazol. Omeprazole may increase the serum concentration of OPC-13015, an active metabolite of Cilostazol.
Management
Monitor for increased effects of cilostazol when coadministered with omeprazole. Consider a 50% dose reduction of cilostazol (eg, 100 mg twice daily to 50 mg twice daily) with concomitant use of these agents.

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