Ofloxacin (systemic) vs Didanosine

Interacting Drugs
Ofloxacin (systemic)
vs
Didanosine
Security Level
Moderate, Consider therapy modification
Mechanism
Didanosine: May decrease the serum concentration of Quinolone Antibiotics.
Management
Administer oral quinolones at least 2 hours before or 6 hours after didanosine. Monitor for decreased therapeutic effects of quinolones, particularly if doses cannot be separated as recommended. This does not apply to unbuffered enteric coated didanosine.

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