Moclobemide vs Methadone

Interacting Drugs
Moclobemide
vs
Methadone
Security Level
Moderate, Consider therapy modification
Mechanism
Methadone: MAO Inhibitors may enhance the adverse/toxic effect of Methadone.
Management
Initial safety testing, where small incremental doses of methadone are given with the patient closely monitored (including vitals, etc.), is recommended if methadone is to be used with (or within 14 days of) an MAO inhibitor. Avoid transdermal selegiline.

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Other Interactions of Methadone

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