Midazolam vs Protease Inhibitors

Interacting Drugs
Midazolam
vs
Protease Inhibitors
Security Level
Major, Avoid combination
Mechanism
Protease Inhibitors: May increase the serum concentration of Midazolam.
Management
Oral midazolam contraindicated with all protease inhibitors. IV midazolam contraindicated with fosamprenavir and nelfinavir; other protease inhibitors recommend caution, close monitoring, and consideration of lower IV midazolam doses with concurrent use.

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