Mesalamine vs H2-Antagonists

Interacting Drugs
Mesalamine
vs
H2-Antagonists
Security Level
Moderate, Consider therapy modification
Mechanism
H2-Antagonists: May diminish the therapeutic effect of Mesalamine. Histamine H2-Antagonist-mediated increases in gastrointestinal pH may cause the premature release of mesalamine from specific sustained-release mesalamine products.
Management
Consider avoiding concurrent administration of high-dose histamine H2-receptor antagonists with sustained-release mesalamine products.

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Other Interactions of H2-Antagonists

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