Magnesium sulfate vs Sodium Polystyrene Sulfonate

Interacting Drugs
Magnesium sulfate
vs
Sodium Polystyrene Sulfonate
Security Level
Major, Avoid combination
Mechanism
Sodium Polystyrene Sulfonate: Laxatives may enhance the adverse/toxic effect of Sodium Polystyrene Sulfonate. More specifically, concomitant use of sodium polystyrene sulfonate with magnesium-containing laxatives may result in metabolic alkalosis or with sorbitol may result in intestinal necrosis.
Management
Avoid concomitant use of sodium polystyrene sulfonate (rectal or oral) and magnesium-containing laxatives or sorbitol.

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