Magnesium carbonate, calcium carbonate, and folic acid vs Calcium Polystyrene Sulfonate

Interacting Drugs
Magnesium carbonate, calcium carbonate, and folic acid
vs
Calcium Polystyrene Sulfonate
Security Level
Moderate, Consider therapy modification
Mechanism
Calcium Polystyrene Sulfonate: Antacids may enhance the adverse/toxic effect of Calcium Polystyrene Sulfonate. The combined use of these two agents may result in metabolic alkalosis and/or loss of efficacy of the cation exchange resin.
Management
To minimize this interaction, consider: a)separating doses by 2 or more hours; b)rectal administration of the exchange resin; or c)alternatives to antacids. Monitor for metabolic alkalosis and attenuation of CPS effects. Avoid magnesium hydroxide.

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